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Case Reports: Unusual presentation of more common disease/injury
Paraneoplastic anti-TIF1-gamma-positive dermatomyositis as expression of cervical squamous cell carcinoma recurrence
  1. Mirthe A J M van Erp1,
  2. Frank M A Slaats2,
  3. Judith M A Emmen3 and
  4. Dennis van Hamont1
  1. 1Department of Obstetrics and Gynaecology, Amphia Hospital, Breda, The Netherlands
  2. 2Department of Rheumatology, Amphia Hospital, Breda, The Netherlands
  3. 3Result Laboratory of Clinical Chemistry and Haematology, Amphia Hospital, Breda, The Netherlands
  1. Correspondence to Mirthe A J M van Erp; mvanerp{at}amphia.nl

Abstract

Idiopathic inflammatory myopathies are neuromuscular disorders characterised by muscle weakness and histologically inflammation within the muscle. Dermatomyositis and polymyositis are highly associated with a wide range of cancers, especially in antitranscriptional intermediary factor-1 (TIF1)-gamma-positive myositis. We present a case of paraneoplastic dermatomyositis in a patient with a medical history of a FIGO stage 1B1 cervical squamous cell carcinoma. Anti-TIF1-gamma autoantibodies were detected by myositis lineblot analysis and a PET-CT scan revealed an abnormality positioned at the right ovary. She underwent laparoscopic exploration and pathological analysis of the PET-positive abnormality showed a lymphogenic metastasis of a squamous cell carcinoma, competitive with cervical carcinoma recurrence. She started chemoradiation as curative oncological treatment. The dermatomyositis was successfully treated with high-dose corticosteroids. Physicians should be aware of the association between myositis and the increased risk of malignancies.

  • musculoskeletal and joint disorders
  • obstetrics, gynaecology and fertility
  • skin
  • musculoskeletal syndromes
  • cervical cancer

https://doi.org/10.1136/bcr-2022-253636

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    Footnotes

    • Contributors ME, FMAS, JMAE and DvH contributed to conception and design, acquisition of data and interpretation of data. ME drafted article. FMAS, JMAE and DvH critically revised the article for important intellectual content. All authors gave final approval of the version published.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.