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Case Reports: Adverse drug reactions and complications
Unexpected cause of Kounis syndrome: hypersensitivity reaction to omeprazole
  1. Almina Erdem1,
  2. Tufan Çınar2,
  3. Şahhan Kılıç1 and
  4. Nazlı Begüm Öztürk3
  1. 1Cardiology, Istanbul Sultan II Abdulhamid Han Egitim ve Arastirma Hastanesi, Istanbul, Turkey
  2. 2İnternal Medicine, University of Maryland Midtown Campus, Baltimore, Maryland, USA
  3. 3Internal Medicine, Beaumont Hospital, Royal Oak, Michigan, USA
  1. Correspondence to Dr Nazlı Begüm Öztürk; nazlibegumozturk{at}gmail.com

Abstract

Kounis syndrome is a rare type of acute coronary syndrome (ACS) that occurs as a result of an allergic or anaphylactic reaction. Kounis syndrome can be induced by various medications including antibiotics, proton pump inhibitors, antihypertensive medications, corticosteroids, and antineoplastic medications. Additionally, cases of Kounis syndrome associated with lansoprazole and pantoprazole have been previously reported in the literature. In this report, we present a case of Kounis syndrome associated with omeprazole use, and discuss the need for a high index of suspicion as it is often underrecognised.

  • Interventional cardiology
  • Ischaemic heart disease
  • Clinical diagnostic tests
  • Drugs: gastrointestinal system
  • Allergy, asthma

https://doi.org/10.1136/bcr-2023-254799

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    Footnotes

    • Twitter @alminaerdem, @nbegumozturkmd

    • Contributors The following authors were responsible for drafting of the text: AE, TÇ, ŞK, NBO. Data collection and processing: AE, TÇ, ŞK, NBO. Sourcing and editing of clinical images: AE, TÇ, ŞK. Concept and design: AE, ŞK, NBO. Literature search: AE, ŞK, NBO. Investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: AE, TÇ. The following authors gave final approval of the manuscript: AE, TÇ, ŞK, NBO.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.