Accuracy measures of CCE and CTC in the detection of polyps ≥10 mm, assessed in relation to confirmatory OC results
| Analysis set | Whole colon Rex | ||
| FAS (N=145) | PPAS (N=133) | ||
| CCE | Sensitivity, % (95% CI) | 76.0 (56.2 to 88.8) | 85.7 (64.5 to 95.9) |
| Specificity, % (95% CI) | 98.3 (93.8 to 99.9) | 98.2 (93.3 to 99.9) | |
| PPV (95% CI) | 90.5 (69.9 to 98.6) | 90.0 (68.7 to 98.4) | |
| NPV (95% CI) | 95.2 (89.6 to 98.0) | 97.3 (92.1 to 99.4) | |
| Analysis set | FAS (N=141) | PPAS (N=128) | |
| CTC | Sensitivity, % (95% CI) | 50.0 (28.0 to 72.0) | 50.0 (28.0 to 72.0) |
| Specificity, % (95% CI) | 98.4 (94.0 to 99.9) | 99.1 (94.6 to 100.0) | |
| PPV (95% CI) | 80.0 (47.9 to 95.4) | 88.9 (54.3 to 100.0) | |
| NPV (95% CI) | 93.9 (88.2 to 97.0) | 93.3 (87.1 to 96.7) | |
Results reported are from unblinded, unadjudicated, central reader data set. The study was not powered to assess ≥10 mm polyps.
CCE, colon capsule endoscopy; CTC, CT colonography; FAS, full analysis set; NPV, negative predictive value; OC, optical colonoscopy; PPAS, per-protocol analysis set; PPV, positive predictive value.