Accuracy measures of CCE and CTC for the detection of polyps ≥6 mm, assessed in relation to confirmatory OC results
| Analysis set | Whole colon Rex method | ||
| FAS (N=145) | PPAS (N=133) | ||
| CCE | Sensitivity, % (95% CI) | 74.6 (62.1 to 84.0) | 79.2 (66.4 to 88.2) |
| Specificity, % (95% CI) | 96.5 (89.8 to 99.2) | 96.3 (89.1 to 99.2) | |
| PPV (95% CI) | 93.6 (82.2 to 98.4) | 93.3 (81.5 to 98.4) | |
| NPV (95% CI) | 84.7 (76.2 to 90.6) | 87.5 (78.8 to 93.0) | |
| Analysis set | FAS (N=141) | PPAS (N=128) | |
| CTC | Sensitivity, % (95% CI) | 22.9 (13.1 to 36.7) | 26.8 (15.6 to 42.1) |
| Specificity, % (95% CI) | 97.8 (92.0 to 99.9) | 98.9 (93.2 to 100.0) | |
| PPV (95% CI) | 84.6 (56.5 to 96.9) | 91.7 (62.5 to 100.0) | |
| NPV (95% CI) | 71.1 (62.7 to 78.3) | 74.1 (65.4 to 81.3) | |
CCE, colon capsule endoscopy; CTC, CT colonography; FAS, full analysis set; NPV, negative predictive value; OC, optical colonoscopy; PPAS, per-protocol analysis set; PPV, positive predictive value.