Table 1

Demographic and clinical details of patients with tTG titres≥10×ULN where villous abnormalities were not detected on duodenal biopsies

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
Age (years)	34	42	43	33	46
Gender	Female	Male	Female	Male	Female
Presenting symptoms	Diarrhoea with urgency	Diarrhoea, abdominal pain	Iron deficiency anaemia, diarrhoea	Abdominal pain, bloating, tiredness	Iron deficiency anaemia
HLA status	DQ2 heterozygous	DQ2 homozygous	DQ2 heterozygous	DQ2 homozygous	DQ2 homozygous
EMA test	Negative	Positive	Negative	Positive	Negative
Family history of CD?	No	No	No	No	No
TTG at diagnosis	300	300	211	292	182
Marsh grade at diagnosis	Marsh 1	Marsh 2	Marsh 2	Marsh 1	Normal
TTG post-GFD	1	8	6	111	1

CD, coeliac disease; EMA, endomysial antibody; GFD, gluten free diet; HLA, human leucocyte antigen; tTG, tissue transglutaminase.