Recommended interval for discontinuation of antiplatelet and anticoagulant medication prior to liver biopsy
| Drug | Dose | Stop | Notes |
| Clopidogrel, prasugrel, ticagrelor | 7 Days | If cannot delay for 7 days stop clopidogrel for 24 hours; platelet transfusion may be used but transjugular liver biopsy route is recommended | |
| Aspirin | 3–7 Days prior to elective procedures | For urgent biopsies, aspirin can be continued at the discretion of the clinician | |
| Dual antiplatelet therapy—for example, aspirin/clopidogrel | Consider if biopsy can be delayed or if clopidogrel can be stopped. Always continue aspirin | Many patients receiving this antiplatelet combination have cardiac stents | |
| Dipyridamole | Omit on day of biopsy | ||
| Low molecular weight heparin | Prophylactic dose | 12 Hours before procedure | |
| Higher than prophylactic dose | 24 Hours before procedure | ||
| Direct oral anticoagulants | Omit for 2 days before procedure | Omit for longer if dabigatran and renal impairment |