Histological and serological based risk stratification and detection of HDG/gastric cancer during follow-up
P=0.49 | Tmax | |
HDG/gastric cancer | ||
3 (1.4%) | ||
Low risk | 29 | 0 (0%) |
High risk | 182 | 3 (1.6%) |
Based on both histological and serological results, patients were categorised into a low-risk or high-risk group. Low risk was defined as AG/IM limited to antrum and normal biomarkers (no Helicobacter pylori, normal PGI/PGII and G-17 levels). High-risk group was defined as AG/IM in both antrum and corpus and/or abnormal biomarkers.
Mean follow-up time was 50.8 months (SD 32). Missing n=68 (including one gastric cancer case), as only patients who underwent at least two surveillance endoscopies during follow-up were included.
AG, atrophic pangastritis; HDG, high-grade adenoma/dysplasia; IM, intestinal metaplasia; G-17, gastrin-17; PGI, pepsinogen I; PGII, pepsinogen II.