Test performance per screening test in asymptomatic, average-risk adults
| gFOBT | FIT | FS | CTC | Colonoscopy | |
|---|---|---|---|---|---|
| Sensitivity (%) for detecting advanced neoplasia | 9 to 2443–48 | 32 to 5343 44 47 49 | 90 to 92*50 | 8835 to 9743 | 88 to 9851 |
| Sensitivity (%) for detecting CRC | 13 to 5044–46 | 79 52 | 90 to 92*50 | 100†53 | 92 to 9950 |
| Reduction in CRC incidence (%) intention-to-screen | No‡19 54 | Unknown | 1854 | Unknown | 69§55 |
| Reduction in CRC mortality (%) intention-to-screen | 14 to 1619 | 22¶25 | 2854 | Unknown | 68§55 |
*Sensitivity is given for the distal colon.
†No CRCs were missed by CTC in six screening trials.
‡No reduction in incidence was found in three of four RCTs included in meta-analysis.
§ Meta-analysis of observational studies, more results expected.
¶ Ecological study.
CRC, colorectal cancer; CTC, CT colonography; FIT, faecal immunochemical test for haemoglobin; FS, flexible sigmoidoscopy; gFOBT, guaiac faecal occult blood test; RCT, randomised controlled trial.