Patient preferences and true stool responder data
| Ondansetron No Placebo Yes | Ondansetron Yes Placebo No | Ondansetron No Placebo No | Ondansetron Yes Placebo Yes | Risk ratio to prefer ‘ondansetron but not placebo’ compared with ‘placebo but not ondansetron’ | |
|---|---|---|---|---|---|
| ITT (N=94) | |||||
| Preference, N (%) | 15 (16) | 70 (74) | 9 (10) | 0 (0) | 4.7 (2.7 to 8.2) |
| p value | <0.001 | ||||
| Continue, N (%) | 15 (16) | 67 (71) | 11 (12) | 1 (1) | 4.5 (2.6 to 7.8) |
| p value | <0.001 | ||||
| Adequate Relief, N (%) | 13 (14) | 61 (65) | 17 (18) | 3 (3) | 4.7 (2.6 to 8.5) |
| p value | <0.001 | ||||
| PPA (N=86) | |||||
| Preference, N (%) | 13 (15) | 66 (77) | 7 (8) | 0 (0) | 5.1 (2.8 to 9.2) |
| p value | <0.001 | ||||
| Continue, N (%) | 14 (16) | 64 (74) | 7 (8) | 1 (1) | 4.6 (2.6 to 8.2) |
| p value | <0.001 | ||||
| Adequate Relief, N(%) | 11 (13) | 58 (67) | 14 (16) | 3 (3) | 5.3 (2.8 to 10.0) |
| p value | <0.001 | ||||
| Response data | |||||
| ITT (N=98) | |||||
| True stool responder | |||||
| Response, N (%) | 6 (6) | 44 (45) | 14 (14) | 34 (35) | 7.3 (3.1 to 17.2) |
| p value | <0.001 | ||||
| PPA (N=90) | |||||
| Response, N (%) | 5 (6) | 43 (48) | 11 (12) | 31 (34) | 8.6 (3.4 to 21.7) |
| p value | <0.001 | ||||
*Ratios are shown for probability that people would prefer a particular choice compared with the choice ‘Placebo yes but ondansetron no’. For example, it is much more probable (4.2 times, 95% CI 2.5 to 7.1) that patients prefer ‘Ondansetron but not placebo’ compared with ‘Placebo but not ondansetron’. The same applies to ‘continue’ and ‘adequate relief’ options. Data show that it is more probable (7.3 times, 95% CI 3.1 to 17.2) to respond to ondansetron but not placebo compared with placebo but not ondansetron.