Overview of apoptosis-associated transcripts regulated by infliximab (IFX)
Effect of IFX | Gene | Name | Function | Reference |
Downregulation | CIAPIN1 | Cytokine-induced apoptosis inhibitor 1 | Anti-apoptotic | 19 |
API5 | Apoptosis inhibitor 5 | Anti-apoptotic | 20 | |
Upregulation | PDCD4 | Programmed cell death 4 | Anti-proliferative, pro-apoptotic | 21 |
PDCD6 | Programmed cell death 6 | Ca2+ binding, pro-apoptotic | 23 | |
BTG1 | B-cell translocation gene 1 | Pro-apoptotic, anti-proliferative | 24 | |
BIRC4BP | XIAP associated factor 1 | Pro-apoptotic, antagonist of XIAP | 22 | |
BNIP3L | BCL2/adenovirus E1B 19 kDa interacting protein 3-like | Pro-apoptotic, target of p53 | 25 |
BCL2, B-cell lymphoma 2; XIAP, X-linked inhibitor of apoptosis.