Gut: 74 (4)

Commentaries

Targeting Wnt signalling through LINC02418: insights from CRISPR screens (20 February, 2025)
Zekiye Altan, Rory Johnson
High-risk varices in patients with Child-Pugh-Turcotte B and C: consider band ligation with carvedilol for preventing first variceal bleeding, especially in patients with MASLD-associated cirrhosis (18 September, 2024)
Alexander Zipprich, Ruben Hernaez
Statins for MAFLD/MASH: another brick in the wall while waiting for final answers (18 September, 2024)
Jaime Bosch
Treatment of type 2 diabetes with MASLD: new evidence for personalised medicine (24 October, 2024)
Cyrielle Caussy

Stomach

Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression (20 November, 2024)
Sarah S K Yue, Yin Tong, Hoi Cheong Siu, Siu Lun Ho, Simon Y K Law, Wai Yin Tsui, Dessy Chan, Yuanhua Huang, Annie S Y Chan, Shui Wa Yun, Ho Sang Hui, Jee-Eun Choi, Matthew S S Hsu, Frank P L Lai, April S Chan, Siu Tsan Yuen, Hans Clevers, Suet Yi Leung, Helen H N Yan

Inflammatory bowel disease

Early tumour necrosis factor antagonist treatment prevents perianal fistula development in children with Crohn’s disease: post hoc analysis of the RISK study (12 December, 2024)
Jeremy Adler, Samir Gadepalli, Moshiur Rahman, Sandra Kim
Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy – a multi-arm randomised controlled trial (HELIOS) (16 January, 2025)
Maarten te Groen, Anouk M Wijnands, Nathan den Broeder, Dirk J de Jong, Willemijn A van Dop, Marjolijn Duijvestein, Herma H Fidder, Fiona van Schaik, Meike M C Hirdes, Andrea E van der Meulen-de Jong, P W Jeroen Maljaars, Philip W Voorneveld, K H Nanne de Boer, Charlotte P Peters, Bas Oldenburg, Frank Hoentjen

Gut microbiota

Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway
(9 December, 2024)
Zhuangzhuang Shi, Min Li, Chen Zhang, Hongwen Li, Yue Zhang, Lei Zhang, Xin Li, Ling Li, Xinhua Wang, Xiaorui Fu, Zhenchang Sun, Xudong Zhang, Li Tian, Mingzhi Zhang, Wei-Hua Chen, Zhaoming Li

Colon

Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome (19 November, 2024)
Laura J Schwarzmueller, Ronja S Adam, Leandro F Moreno, Lisanne E Nijman, Adrian Logiantara, Steven Eleonora, Oscar Bril, Sophie Vromans, Nina E de Groot, Francesca Paola Giugliano, Ekaterina Stepanova, Vanesa Muncan, Clara C Elbers, Kristiaan J Lenos, Danny A Zwijnenburg, Monique A J van Eijndhoven, Dirk Michiel Pegtel, Sanne M van Neerven, Fabricio Loayza-Puch, Tulin Dadali, Wendy J Broom, Martin A Maier, Jan Koster, Louis Vermeulen, Nicolas Léveillé
Original research: Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer (10 December, 2024)
Ramani Soundararajan, Michelle M Maurin, Jetsen Rodriguez-Silva, Gunjan Upadhyay, Ashley J Alden, Siddabasave Gowda B Gowda, Michael J Schell, Mingli Yang, Noah Jhad Levine, Divyavani Gowda, Punith M Sundaraswamy, Shu-Ping Hui, Lance Pflieger, Heiman Wang, Jorge Marcet, Carolina Martinez, Robert David Bennett, Allen Chudzinski, Andreas Karachristos, Timothy M Nywening, Paul M Cavallaro, Matthew Linley Anderson, Robert J Coffey, Michael V Nebozhyn, Andrey Loboda, Domenico Coppola, Warren Jackson Pledger, Ganesh V Halade, Timothy J Yeatman

Pancreas

Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus (2 January, 2025)
Jing Tong Tan, Xianhua Mao, Ho-Ming Cheng, Wai-Kay Seto, Wai-K Leung, Ka-Shing Cheung

Hepatology

Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma (1 November, 2024)
Yalin Tu, Haoran Wu, Chengpeng Zhong, Yan Liu, Zhewen Xiong, Siyun Chen, Jing Wang, Patrick Pak-Chun Wong, Weiqin Yang, Zhixian Liang, Jiahuan Lu, Shufen Chen, Lingyun Zhang, Yu Feng, Willis Wai-Yiu Si-Tou, Baoyi Yin, Yingnan Lin, Jianxin Liang, Liying Liang, Joaquim S L Vong, Weida Ren, Tsz Tung Kwong, Howard Leung, Ka Fai To, Stephanie Ma, Man Tong, Hanyong Sun, Qiang Xia, Jingying Zhou, David Kerr, Nick La Thangue, Joseph J Y Sung, Stephen Lam Chan, Alfred Sze-Lok Cheng
Effects of tenofovir disoproxil fumarate on intrahepatic viral burden and liver immune microenvironment in patients with chronic hepatitis B (8 October, 2024) Free
David Z Pan, Cameron M Soulette, Abhishek Aggarwal, Dong Han, Nicholas van Buuren, Peiwen Wu, Becket Feierbach, Jaw-Town Lin, Cheng-Hao Tseng, Chi-Yi Chen, Bryan Downie, Hongmei Mo, Lauri Diehl, Li Li, Simon P Fletcher, Scott Balsitis, Ricardo Ramirez, Vithika Suri, Yao-Chun Hsu
Original research: Hepatic TM6SF2 activates antitumour immunity to suppress metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma and boosts immunotherapy (12 December, 2024)
Yating Zhang, Mingxu Xie, Jun Wen, Cong Liang, Qian Song, Weixin Liu, Yali Liu, Yang Song, Harry Cheuk Hay Lau, Alvin Ho-Kwan Cheung, Kwan Man, Jun Yu, Xiang Zhang

Recent advances in basic science

Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD (11 September, 2024)
Giorgos Bamias, Paola Menghini, Theresa T Pizarro, Fabio Cominelli

Recent advances in clinical practice

Metabolic dysfunction-associated steatotic liver disease in children (23 January, 2025)
Nidhi P Goyal, Stavra Xanthakos, Jeffrey B Schwimmer

PostScript

AlphaMissense versus laboratory-based pathogenicity prediction of 13 novel missense CPA1 variants from pancreatitis cases
(10 September, 2024)
Máté Sándor, Isabelle Scheers, Atsushi Masamune, Heiko Witt, Jessica LaRusch, Jian-Min Chen, Balázs Csaba Németh, Andrea Geisz, Aliye Uc, Miklós Sahin-Tóth
Extending inflamed-class signature to predict immune checkpoint inhibitor-based combination therapy in hepatocellular carcinoma (11 September, 2024)
Wenhua You, Chupeng Hu, Mengya Zhao, Yuhan Zhang, Jinying Lu, Yedi Huang, Ling Li, Yun Chen
Cold EMR, hot EMR or ESD for large benign adenoma: not one size fits all (17 September, 2024)
Veronique Van der Voort, Cesare Hassan, Alessandro Repici, Romain Legros, Mathieu Pioche, Jérémie Jacques
Variceal band ligation and carvedilol: together forever, or not? (25 September, 2024)
Philip D J Dunne, Ewan H Forrest, Adrian J Stanley
Rethinking routine mapping biopsies in gastric intestinal metaplasia: justification for endoscopic stratification (19 September, 2024)
Duc Trong Quach, Toru Hiyama, Gwang Ha Kim, Takuji Gotoda, Kentaro Sugano
Unravelling lipidomic disruptions across multiple tissues in Chd8-mutant ASD mice through integration of lipidomics and single-cell transcriptomics
(2 October, 2024)
You Yu, Bing Zhang, Ning Wang, Zhenqiang Zuo, Peifeng Ji, Fangqing Zhao
Novel mouse model for studying transmural intestinal fibrosis and creeping fat formation in stricturing Crohn’s disease (14 October, 2024)
Xiaofen Lv, Yunqing Zeng, Wenlong Ma, Yuan Zheng, Tengkai Wang, Mingru Liu, Di Zhang, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu
Environmental and healthcare trade-offs between single-use and reusable gastroscopes (2 October, 2024)
Jiashu Han, Dan Shan
Exploring the role of genetics, gut microbiota and blood metabolites in IBD (4 October, 2024)
Yiwen Yuan, Xi Fu, Yiqun Deng, Yu Sun
Is the biogeography of the mucosa-associated microbiota a key factor affecting primary sclerosing cholangitis disease course and treatment? (20 December, 2024)
Yenkai Lim, Seungha Kang, Ayesha Shah, Gerald Holtmann, Mark Morrison

JournalScan

GI highlights from the literature (6 March, 2025)
Philip J Smith

Editor’s quiz: GI snapshot

Perplexing case of abdominal pain with eosinophilia and fasciitis (6 May, 2024)
Robert Sean O'Neill, Logan Gardner, Anthony Kelleher, Roger Pamphlett, Laila Girgis, Alina Stoita

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Table of contents

April 2025 - Volume 74 - 4

Commentaries

Stomach

Inflammatory bowel disease

Gut microbiota

Colon

Pancreas

Hepatology

Recent advances in basic science

Recent advances in clinical practice

PostScript

JournalScan

Editor’s quiz: GI snapshot

Issue Information

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Table of contents

April 2025 - Volume 74 - 4

Commentaries

Stomach

Inflammatory bowel disease

Gut microbiota

Colon

Pancreas

Hepatology

Recent advances in basic science

Recent advances in clinical practice

PostScript

JournalScan

Editor’s quiz: GI snapshot

Issue Information