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Contributors JL and LL: conception and design of the study. JX, LJ, QZ, DS, LZ, CH and XX: acquisition of data. WD, SH and JL: analysis and interpretation of data. LL and WD: drafting of the manuscript. JL, LL, WD and SH: critical revision of the manuscript for important intellectual content. WD, SH, XC and JZ: statistical analysis. JX, LJ, QZ, DS, LZ and XX: technical or material support. JL and LL: study supervision.
Funding National S&T Major Project, Chinese High-Tech Research and Development (863) Programme, the Zhejiang Provincial and National Natural Science Foundation of China.
Competing interests None declared.
Patient consent Obtained.
Ethics approval The Clinical Research Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine.
Provenance and peer review Not commissioned; internally peer reviewed.
JX, WD and SH contributed equally.