COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects: a double blind crossover study comparing rofecoxib with placebo and indomethacin

G Sigthorsson; R Crane; T Simon; M Hoover; H Quan; J Bolognese; I Bjarnason

doi:10.1136/gut.47.4.527

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Small intestinal disease

COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects: a double blind crossover study comparing rofecoxib with placebo and indomethacin

Online download statistics by month:

Online download statistics by month: September 2000 to April 2025

	Abstract	Full	Pdf
Sep 2000	68	125	68
Oct 2000	36	113	42
Nov 2000	7	51	22
Dec 2000	9	35	8
Jan 2001	7	23	16
Feb 2001	7	36	17
Mar 2001	2	24	15
Apr 2001	12	17	6
May 2001	4	21	5
Jun 2001	2	15	0
Jul 2001	3	9	1
Aug 2001	3	11	7
Sep 2001	4	9	2
Oct 2001	7	15	7
Nov 2001	7	12	3
Dec 2001	3	6	9
Jan 2002	2	22	6
Feb 2002	0	11	3
Mar 2002	3	21	8
Apr 2002	4	15	3
May 2002	0	5	1
Jun 2002	7	15	4
Jul 2002	2	9	6
Aug 2002	1	5	3
Sep 2002	0	18	7
Oct 2002	4	6	6
Nov 2002	4	7	4
Dec 2002	4	10	5
Jan 2003	4	13	11
Feb 2003	2	6	9
Mar 2003	6	6	6
Apr 2003	6	5	11
May 2003	3	14	13
Jun 2003	4	5	12
Jul 2003	15	18	16
Aug 2003	17	9	10
Sep 2003	15	15	4
Oct 2003	18	14	5
Nov 2003	16	7	5
Dec 2003	13	12	7
Jan 2004	20	12	5
Feb 2004	18	7	7
Mar 2004	22	15	9
Apr 2004	17	8	5
May 2004	39	38	4
Jun 2004	46	45	8
Jul 2004	54	59	7
Aug 2004	40	47	4
Sep 2004	39	43	14
Oct 2004	17	57	18
Nov 2004	7	62	13
Dec 2004	12	31	5
Jan 2005	12	22	6
Feb 2005	13	29	5
Mar 2005	7	25	17
Apr 2005	10	22	40
May 2005	14	15	11
Jun 2005	12	14	8
Jul 2005	8	17	8
Aug 2005	5	25	9
Sep 2005	10	21	17
Oct 2005	14	15	5
Nov 2005	10	12	3
Dec 2005	8	17	4
Jan 2006	12	12	4
Feb 2006	9	25	14
Mar 2006	0	8	4
Apr 2006	9	11	4
May 2006	9	6	4
Jun 2006	14	11	6
Jul 2006	6	17	9
Aug 2006	2	6	1
Sep 2006	4	10	7
Oct 2006	15	25	12
Nov 2006	8	18	10
Dec 2006	6	12	3
Jan 2007	12	14	2
Feb 2007	11	18	5
Mar 2007	13	19	8
Apr 2007	18	8	4
May 2007	12	7	4
Jun 2007	16	4	6
Jul 2007	9	1	2
Aug 2007	17	2	0
Sep 2007	11	7	3
Oct 2007	12	4	4
Nov 2007	8	1	4
Dec 2007	6	5	3
Jan 2008	3	2	0
Feb 2008	3	3	2
Mar 2008	12	6	7
Apr 2008	9	5	3
May 2008	14	1	1
Jun 2008	6	2	1
Jul 2008	24	0	1
Aug 2008	20	2	0
Sep 2008	9	1	2
Oct 2008	19	2	1
Nov 2008	17	2	3
Dec 2008	10	1	0
Jan 2009	5	1	0
Feb 2009	26	2	2
Mar 2009	24	1	0
Apr 2009	15	1	1
May 2009	6	2	2
Jun 2009	6	1	2
Jul 2009	5	0	1
Aug 2009	8	2	2
Sep 2009	8	4	4
Oct 2009	10	6	5
Nov 2009	11	1	0
Dec 2009	7	1	0
Jan 2010	8	6	4
Feb 2010	7	1	2
Mar 2010	8	5	5
Apr 2010	7	6	2
May 2010	5	0	0
Jun 2010	7	2	2
Jul 2010	4	1	4
Aug 2010	10	4	1
Sep 2010	12	0	1
Oct 2010	4	0	0
Nov 2010	17	1	0
Dec 2010	6	1	2
Jan 2011	11	2	1
Feb 2011	7	1	2
Mar 2011	14	1	1
Apr 2011	6	0	0
May 2011	5	4	1
Jun 2011	4	2	0
Jul 2011	5	0	1
Aug 2011	8	0	0
Sep 2011	10	0	2
Oct 2011	20	0	1
Nov 2011	15	4	5
Dec 2011	13	6	5
Jan 2012	9	3	3
Feb 2012	11	5	3
Mar 2012	11	7	8
Apr 2012	6	8	6
May 2012	15	6	4
Jun 2012	8	3	6
Jul 2012	9	3	6
Aug 2012	7	8	11
Sep 2012	6	6	8
Oct 2012	15	13	4
Nov 2012	14	6	5
Dec 2012	9	4	7
Jan 2013	11	4	6
Feb 2013	12	10	7
Mar 2013	7	5	6
Apr 2013	15	7	8
May 2013	6	9	7
Jun 2013	5	0	1
Jul 2013	6	8	0
Aug 2013	7	7	5
Sep 2013	12	4	4
Oct 2013	16	6	6
Nov 2013	5	3	3
Dec 2013	21	40	1
Jan 2014	11	9	4
Feb 2014	8	2	4
Mar 2014	10	11	2
Apr 2014	6	17	12
May 2014	12	13	14
Jun 2014	6	11	8
Jul 2014	19	13	4
Aug 2014	8	6	2
Sep 2014	9	3	0
Oct 2014	8	1	1
Nov 2014	1	5	4
Dec 2014	5	2	2
Jan 2015	7	2	3
Feb 2015	6	4	5
Mar 2015	16	11	3
Apr 2015	5	5	0
May 2015	4	0	1
Jun 2015	7	3	3
Jul 2015	8	1	4
Aug 2015	2	2	0
Sep 2015	4	3	3
Oct 2015	7	3	4
Nov 2015	10	12	1
Dec 2015	15	4	3
Jan 2016	14	1	4
Feb 2016	6	2	6
Mar 2016	4	3	9
Apr 2016	10	1	7
May 2016	4	9	6
Jun 2016	8	3	0
Jul 2016	8	0	2
Aug 2016	33	4	3
Sep 2016	10	1	5
Oct 2016	9	4	4
Nov 2016	13	5	2
Dec 2016	19	6	1
Jan 2017	17	1	4
Feb 2017	9	2	3
Mar 2017	2	4	2
Apr 2017	0	20	3
May 2017	0	12	0
Jun 2017	6	8	4
Jul 2017	16	14	5
Aug 2017	10	10	0
Sep 2017	13	11	3
Oct 2017	15	13	4
Nov 2017	22	18	4
Dec 2017	19	13	0
Jan 2018	7	7	0
Feb 2018	12	12	6
Mar 2018	12	10	2
Apr 2018	19	19	1
May 2018	13	13	1
Jun 2018	23	23	1
Jul 2018	5	5	1
Aug 2018	7	7	1
Sep 2018	7	7	0
Oct 2018	26	26	3
Nov 2018	42	42	1
Dec 2018	35	35	1
Jan 2019	30	30	0
Feb 2019	31	29	6
Mar 2019	24	17	8
Apr 2019	11	7	4
May 2019	9	9	5
Jun 2019	9	9	16
Jul 2019	10	10	10
Aug 2019	6	6	2
Sep 2019	7	7	1
Oct 2019	26	14	3
Nov 2019	9	7	8
Dec 2019	12	7	3
Jan 2020	13	11	7
Feb 2020	26	24	5
Mar 2020	10	8	6
Apr 2020	14	12	3
May 2020	3	3	6
Jun 2020	12	10	5
Jul 2020	14	14	3
Aug 2020	12	12	5
Sep 2020	17	14	3
Oct 2020	12	12	11
Nov 2020	19	19	4
Dec 2020	20	14	10
Jan 2021	10	9	4
Feb 2021	17	17	6
Mar 2021	16	14	1
Apr 2021	12	12	6
May 2021	10	8	3
Jun 2021	7	7	6
Jul 2021	22	22	13
Aug 2021	5	5	2
Sep 2021	13	13	4
Oct 2021	11	11	18
Nov 2021	9	7	19
Dec 2021	5	5	1
Jan 2022	22	17	5
Feb 2022	11	9	4
Mar 2022	20	16	9
Apr 2022	11	10	8
May 2022	22	22	15
Jun 2022	21	19	10
Jul 2022	10	9	2
Aug 2022	25	24	3
Sep 2022	29	24	13
Oct 2022	31	26	10
Nov 2022	15	11	7
Dec 2022	19	19	7
Jan 2023	21	21	4
Feb 2023	44	42	2
Mar 2023	15	13	3
Apr 2023	16	16	1
May 2023	14	8	10
Jun 2023	6	4	1
Jul 2023	16	14	6
Aug 2023	10	10	3
Sep 2023	15	15	10
Oct 2023	17	17	4
Nov 2023	23	22	6
Dec 2023	66	6	0
Jan 2024	32	2	1
Feb 2024	37	1	0
Mar 2024	56	3	1
Apr 2024	20	1	0
May 2024	54	4	2
Jun 2024	18	1	1
Jul 2024	24	0	1
Aug 2024	39	2	0
Sep 2024	13	3	1
Oct 2024	24	0	0
Nov 2024	25	2	1
Dec 2024	40	4	0
Jan 2025	51	0	0
Feb 2025	15	3	0
Mar 2025	10	0	0
Apr 2025	3	1	0
Total	3879	3340	1509

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