The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.

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Volume2, Issue6

December 1975

Pages 509-513

Inhibition of gastric emptying and drug absorption by narcotic analgesics.

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Inhibition of gastric emptying and drug absorption by narcotic analgesics.

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