NIH diagnostic criteria in neurofibramatosis type 1 (NF1). Two or more of the criteria are necessary for a diagnosis of NF1
| Clinical signs |
|---|
| Six or more café au lait spots over 5 mm in greatest diameter in prepubertal individuals and over 15 mm in greatest diameter in postpubertal individuals |
| Two or more neurofibromas of any type or one or more plexiform neurofibroma |
| Freckling in the axillary or inguinal region |
| Optic or chiasma glioma |
| Two or more Lisch nodules (iris hamartomas) |
| A distinctive osseous lesion, such as sphenoid dysplasia or thinning of long bone cortex, with or without bowing and pseudoarthrosis |
| Family history |
| A first degree relative (parent, sibling, or offspring) with NF1 by the above criteria |