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Acute paediatrics
Acute encephalopathy with parvovirus B19 infection in sickle cell disease
  1. S Bakhshi1,
  2. S A Sarnaik1,
  3. C Becker2,
  4. W W Shurney1,
  5. M Nigro3,
  6. S Savaşan1
  1. 1Division of Pediatric Hematology Oncology, Children’s Hospital of Michigan, Detroit, MI 48201, USA
  2. 2Division of Pediatric Imaging, Children’s Hospital of Michigan
  3. 3Division of Pediatric Neurology, Children’s Hospital of Michigan
  1. Correspondence to:
    Dr S Savaşan, Division of Pediatric Hematology Oncology, Children’s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA;
    ssavasan{at}med.wayne.edu

Abstract

A 13 year old girl with haemoglobin Sβ+thalassaemia developed simultaneous aplastic crisis and encephalopathy associated with parvovirus B19 (PB19) infection. Brain magnetic resonance imaging findings were consistent with central nervous system (CNS) vasculitis and her symptoms resolved with steroid therapy. Thus, PB19 induced CNS hypersensitivity vasculitis must be considered in the differential diagnosis of encephalopathy.

  • parvovirus
  • vasculitis
  • sickle cell disease
  • encephalopathy
  • CNS, central nervous system
  • CSF, cerebrospinal fluid
  • EEG, electroencephalogram
  • MRI, magnetic resonance imaging
  • PB19, parvovirus B19
  • PCR, polymerase chain reaction
  • RBC, red blood cell
  • SCD, sickle cell disease
  • WBC, white blood cell

https://doi.org/10.1136/adc.87.6.541

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