Footnotes

• Contributors NS and RBP wrote the manuscript. MDS and RBP edited the manuscript. RBP was involved in the care of the patient.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests MDS conducts clinical trials of vaccines on behalf of the University of Oxford that are funded and/or sponsored by vaccine manufacturers including Glaxosmithkline, Novavax, Pfizer, Medimmune and Sanofi-Pasteur. MDS received no personal financial benefit from these activities. MDS receives salary support from the NIHR Oxford Biomedical Research Centre and is a Jenner Investigator. RBP and NS have no conflicts of interest to declare.

• Patient consent Parental/guardian consent obtained.

• Provenance and peer review Not commissioned; internally peer reviewed.