References

Key articles

National Institute for Health and Care Excellence. Epilepsies in children, young people and adults. April 2022 [internet publication].Full text

Reference articles

1. National Institute for Health and Care Excellence. Epilepsies in children, young people and adults. April 2022 [internet publication].Full text

2. Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus: report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015 Oct;56(10):1515-23.Full text  Abstract

3. Shorvon S. What is nonconvulsive status epilepticus, and what are its subtypes? Epilepsia. 2007;48(suppl 8):35-8.Full text  Abstract

4. Rüegg S. Nonconvulsive status epilepticus in adults: types, pathophysiology, epidemiology, etiology, and diagnosis. Neurology International Open 2017;1:E189-203.Full text

5. Meierkord H, Boon P, Engelsen B, et al. EFNS guideline on the management of status epilepticus in adults. Eur J Neurol. 2010 Mar;17(3):348-55.Full text  Abstract

6. Dham BS, Hunter K, Rincon F. The epidemiology of status epilepticus in the United States. Neurocrit Care. 2014 Jun;20(3):476-83. Abstract

7. DeLorenzo RJ, Hauser WA, Towne AR, et al. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology. 1996 Apr;46(4):1029-35. Abstract

8. Hauser WA. Status epilepticus: epidemiologic considerations. Neurology. 1990 May;40(5 suppl 2):S9-S13. Abstract

9. Trinka E, Höfler J, Zerbs A. Causes of status epilepticus. Epilepsia. 2012 Sep;53 Suppl 4:127-38.Full text  Abstract

10. Craig DP, Mitchell TN, Thomas RH. A tiered strategy for investigating status epilepticus. Seizure. 2020 Feb;75:165-73.Full text  Abstract

11. Walker M. Status epilepticus: an evidence based guide. BMJ. 2005 Sep 24;331(7518):673-7. Abstract

12. Lowenstein DH, Alldredge BK. Status epilepticus. N Engl J Med. 1998 Apr 2;338(14):970-6. Abstract

13. Meldrum BS, Vigouroux RA, Rage P, et al. Hippocampal lesions produced by prolonged seizures in paralyzed artificially ventilated baboons. Experientia. 1973 May 15;29(5):561-3. Abstract

14. Alldredge BK, Lowenstein DH. Status epilepticus related to alcohol abuse. Epilepsia. 1993 Nov-Dec;34(6):1033-7. Abstract

15. Shinnar S. Who is at risk for prolonged seizures? J Child Neurol. 2007 May;22(5 suppl):S14-20. Abstract

16. Crawshaw AA, Cock HR. Medical management of status epilepticus: emergency room to intensive care unit. Seizure. 2020 Feb;75:145-52. Abstract

17. Brophy GM, Bell R, Claassen J, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012 Aug;17(1):3-23. Abstract

18. Chung SS, Gerber P, Kirlin KA. Ictal eye closure is a reliable indicator for psychogenic nonepileptic seizures. Neurology. 2006 Jun 13;66(11):1730-1. Abstract

19. Sutton F, Barca D, Komoltsev I, et al. Testing blood and CSF in people with epilepsy: a practical guide. Epileptic Disord. 2020 Aug 1;22(4):381-98.Full text  Abstract

20. Mills KR. Oxford textbook of clinical neurophysiology. Oxford: Oxford University Press; 2017.

21. Joint Royal Colleges Ambulance Liaison Committee; Association of Ambulance Chief Executives. JRCALC clinical guidelines 2019. Bridgwater: Class Professional Publishing; 2019.

22. Neligan A, Shorvon SD. Prognostic factors, morbidity and mortality in tonic-clonic status epilepticus: a review. Epilepsy Res. 2011 Jan;93(1):1-10. Abstract

23. Novy J, Logroscino G, Rossetti AO. Refractory status epilepticus: a prospective observational study. Epilepsia. 2010 Feb;51(2):251-6.Full text  Abstract

24. Walker MC, Howard RS, Smith SJ, et al. Diagnosis and treatment of status epilepticus on a neurological intensive care unit. QJM. 1996 Dec;89(12):913-20. Abstract

25. Scholtes FB, Renier WO, Meinardi H. Generalized convulsive status epilepticus: causes, therapy, and outcome in 346 patients. Epilepsia. 1994 Sep-Oct;35(5):1104-12. Abstract

26. Kaski D, Cockerell C. Advances in the diagnosis and management of epilepsy in adults. Drug Review. February 2015 [internet publication].Full text

27. Scottish Intercollegiate Guidelines Network. Diagnosis and management of epilepsy in adults: a national clinical guideline. 2018 [internet publication].Full text

28. Glauser T, Shinnar S, Gloss D. Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr. 2016 Jan-Feb;16(1):48-61.Full text  Abstract

29. Reus VI, Fochtmann LJ, Bukstein O, et al. The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder. Am J Psychiatry. 2018 Jan 1;175(1):86-90. Abstract

30. Chamberlain JM, Kapur J, Shinnar S, et al. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial. Lancet. 2020 Apr 11;395(10231):1217-24.Full text  Abstract

31. Pellock JM. Overview: definitions and classifications of seizure emergencies. J Child Neurol. 2007 May;22(5 suppl):S9-S13. Abstract

32. National Institute for Health and Care Excellence. Head injury: assessment and early management. May 2023 [internet publication].Full text

33. Shorvon S. The management of status epilepticus. J Neurol Neurosurg Psychiatry. 2001 Jun;70 suppl 2(suppl 2):II22-7.Full text  Abstract

34. Schabelman E, Kuo D. Glucose before thiamine for Wernicke encephalopathy: a literature review. J Emerg Med. 2011 Nov 21;42(4):488-94. Abstract

35. Prasad M, Krishnan PR, Sequeira R, et al. Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev. 2014 Sep 10;(9):CD003723.Full text  Abstract

36. Medicines and Healthcare products Regulatory Agency. Valproate use by women and girls. Feb 2021 [internet publication].Full text

37. Lyttle MD, Rainford NEA, Gamble C, et al. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet. 2019 May 25;393(10186):2125-34.Full text  Abstract

38. Medicines and Healthcare products Regulatory Agency. Antiepileptic drugs in pregnancy: updated advice following comprehensive safety review. January 2021 [internet publication].Full text

39. European Medicines Agency. Valproate and related substances. June 2018 [internet publication].Full text

40. Epilepsy Action. What to do when someone has a seizure. 2020 [internet publication].Full text

41. National Institute for Health and Care Excellence. Epilepsies in children, young people and adults: diagnosis and management. [9] Evidence review: antiseizure medication for status epilepticus. NICE guideline NG217. Evidence reviews underpinning recommendations 7.1.1 - 7.1.12 the NICE guideline. April 2022 [internet publication].Full text

42. Towne AR, Garnett LK, Waterhouse EJ, et al. The use of topiramate in refractory status epilepticus. Neurology. 2003 Jan 28;60(2):332-4. Abstract

43. Inokuchi R, Ohashi-Fukuda N, Nakamura K, et al. Comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study. Medicine (Baltimore). 2015 Feb;94(7):e555.Full text  Abstract

44. Pieribone VA, Tsai J, Soufflet C, et al. Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy. Epilepsia. 2007 Oct;48(10):1870-4.Full text  Abstract

45. Hesdorffer DC, Logroscino G, Cascino G, et al. Incidence of status epilepticus in Rochester, Minnesota, 1965-1984. Neurology. 1998 Mar;50(3):735-41. Abstract

46. Betjemann JP, Lowenstein DH. Status epilepticus in adults. Lancet Neurol. 2015 Jun;14(6):615-24. Abstract

47. Koubeissi M, Alshekhlee A. In-hospital mortality of generalized convulsive status epilepticus: a large US sample. Neurology. 2007 Aug 28;69(9):886-93. Abstract

48. Shorvon S, Sen A. What is status epilepticus and what do we know about its epidemiology? Seizure. 2020 Feb;75:131-6.Full text  Abstract

49. Neligan A, Shorvon SD. Frequency and prognosis of convulsive status epilepticus of different causes: a systematic review. Arch Neurol. 2010 Aug;67(8):931-40. Abstract

50. Migdady I, Rosenthal ES, Cock HR. Management of status epilepticus: a narrative review. Anaesthesia. 2022 Jan;77 suppl 1:78-91. Abstract

51. Yaffe K, Lowenstein DH. Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. Neurology. 1993 May;43(5):895-900. Abstract

52. Neville BG, Chin RF, Scott RC. Childhood convulsive status epilepticus: epidemiology, management and outcome. Acta Neurol Scand Suppl. 2007;186:21-4. Abstract

53. Jambaque I, Hertz-Pannier L, Mikaeloff Y, et al. Severe memory impairment in a child with bihippocampal injury after status epilepticus. Dev Med Child Neurol. 2006 Mar;48(3):223-6.Full text  Abstract

Comorbidities Manager reference articles

54. O'Driscoll BR, Howard LS, Earis J, et al. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax. 2017 Jun;72(suppl 1):ii1-90Full text  Abstract

55. Royal College of Physicians. National early warning score (NEWS2). Standardising the assessment of acute-illness severity in the NHS. December 2017 [internet publication]Full text

56. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2024 [internet publication]Full text

57. British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma: a national clinical guideline. July 2019 [internet publication]Full text

58. Joint British Diabetes Societies for Inpatient Care. The hospital management of hypoglycaemia in adults with diabetes mellitus. Jan 2023 [internet publication].Full text

59. Joint British Diabetes Societies for Inpatient Care. The management of diabetic ketoacidosis in adults. Mar 2023 [internet publication].Full text

60. Joint British Diabetes Societies for Inpatient Care. The management of the hyperosmolar hyperglycaemic state (HHS) in adults. Feb 2022 [internet publication].Full text

61. Chowdhury TA, Cheston H, Claydon A. Managing adults with diabetes in hospital during an acute illness. BMJ. 2017 Jun 22;357:j2551 Abstract

62. Joint British Diabetes Societies for Inpatient Care. Self-management of diabetes in hospital. Feb 2023 [internet publication].Full text

63. Joint British Diabetes Societies for Inpatient Care. The use of variable rate intravenous insulin infusion (VRIII) in medical inpatients. Oct 2014 [internet publication].Full text

64. Joint British Diabetes Societies for Inpatient Care. A good inpatient diabetes service. Jul 2019 [internet publication].Full text

65. Joint British Diabetes Societies for Inpatient Care. Inpatient care of the frail older adult with diabetes. Feb 2023 [internet publication].Full text

66. Centre for Perioperative Care. Guideline for perioperative care for people with diabetes mellitus undergoing elective and emergency surgery. Dec 2022 [internet publication].Full text

67. National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. Aug 2022 [internet publication].Full text

68. American Diabetes Association Professional Practice Committee. 16. Diabetes care in the hospital: standards of care in diabetes - 2024. Diabetes Care. 2024 Jan 1;47(suppl 1):S295-306.Full text  Abstract

69. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67Full text  Abstract

70. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 Mar 26;360(13):1283-97.Full text  Abstract

71. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010 Mar;137(3):544-51Full text  Abstract

72. National Institute for Health and Care Excellence. Acute kidney injury: prevention, detection and management. Oct 2024 [internet publication].Full text

73. NHS England. Toolkit for general practice in supporting older people living with frailty. March 2017 [internet publication]Full text

74. British Geriatrics Society (BGS), Getting It Right First Time (GIRFT). Six steps to better care for older people in acute hospitals. Jul 2023 [internet publication].Full text

75. Falk Erhag H, Guðnadóttir G, Alfredsson J, et al. The association between the clinical frailty scale and adverse health outcomes in older adults in acute clinical settings: a systematic review of the literature. Clin Interv Aging. 2023 Feb;18:249-61.Full text  Abstract

76. Quinn TJ, Mooijaart SP, Gallacher K, et al. Acute care assessment of older adults living with frailty. BMJ. 2019 Jan 31;364:l13 Abstract

77. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024 Apr;105(4s):S117-S314.Full text  Abstract

78. Fritz Z, Slowther AM, Perkins GD. Resuscitation policy should focus on the patient, not the decision. BMJ. 2017 Feb 28;356:j813Full text  Abstract

79. British Medical Association, the Resuscitation Council (UK) and the Royal College of Nursing. Decisions relating to cardiopulmonary resuscitation. 2016 [internet publication].Full text

80. National Institute for Health and Care Excellence. Decision making and mental capacity. October 2018 [internet publication]Full text

81. Office of the Public Guardian. Mental Capacity Act: making decisions. Jun 2023 [internet publication]Full text

82. Social Care Institute for Excellence. Independent mental capacity advocate (IMCA). January 2010 [internet publication]Full text

83. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr;21(2):69-72 Abstract

84. National Institute for Health and Care Excellence. Hypertension in adults. Nov 2023 [internet publication].Full text

85. Griffin M, Rao VS, Ivey-Miranda J, et al. Empagliflozin in heart failure: diuretic and cardiorenal effects. Circulation. 2020 Sep 15;142(11):1028-39.Full text  Abstract

86. Verbrugge FH, Grieten L, Mullens W. Management of the cardiorenal syndrome in decompensated heart failure. Cardiorenal Med. 2014 Dec;4(3-4):176-88Full text  Abstract

87. Joint British Diabetes Societies for Inpatient Care. A good inpatient diabetes service. Jul 2019 [internet publication].Full text

88. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication]Full text

89. Rayman G, Vas PR, Baker N, et al. The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration. Diabetes Care. 2011 May 18;34(7):1517-8Full text  Abstract

90. Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004 Jun;125(6):2309-21Full text  Abstract

91. Au DH, Curtis JR, Every NR, et al. Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest. 2002 Mar;121(3):846-51Full text  Abstract

92. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. 2024 [internet publication].Full text

93. Walters JA, Tan DJ, White CJ, et al. Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018 Mar 19;3:CD006897Full text  Abstract

94. National Institute for Health and Care Excellence. Chronic obstructive pulmonary disease in over 16s: diagnosis and management. July 2019 [internet publication]Full text

95. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13 Abstract

96. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011 May;106(5):906-14. Abstract

97. Taylor DM, Barnes TRE, Young AH. The Maudsley prescribing guidelines in psychiatry. 14th edition. Chichester: Wiley-Blackwell; 2021

98. Gupta A, Chadda RK. Adverse psychiatric effects of non-psychotropic medications. BJPsych Advances. 2016;22(5):325-34Full text

99. National Institute for Health and Care Excellence. Depression in adults: treatment and management. Jun 2022 [internet publication]Full text

100. Horowitz M, Taylor DM. The Maudsley deprescribing guidelines: antidepressants, benzodiazepines, gabapentinoids and Z-drugs. Chichester: Wiley-Blackwell; 2024.

101. Cleare A, Pariante CM, Young AH, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2015 May 12;29(5):459-525Full text  Abstract

102. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20. Abstract

103. Buckley NA, Dawson AH, Isbister GK. Serotonin syndrome. BMJ. 2014 Feb 19;348:g1626 Abstract

104. Nochaiwong S, Ruengorn C, Awiphan R, et al. Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis. Ann Med. 2022 Dec;54(1):80-97Full text  Abstract

105. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther. 2008 Jan 1;27(1):31-40Full text  Abstract

106. Michaelis R, Tang V, Nevitt SJ, et al. Psychological treatments for people with epilepsy. Cochrane Database Syst Rev. 2020 Sep 7;8:CD012081Full text  Abstract

107. National Institute for Health and Care Excellence. Liaison psychiatry. In: Emergency acute medical care in over 16s: service delivery and organisation. March 2018 [internet publication]Full text

108. National Confidential Enquiry into Patient Outcome and Death (NCEPOD). Treat as one. Bridging the gap between mental and physical healthcare in general hospitals. 2017 [internet publication]Full text

109. National Institute for Health and Care Excellence. Epilepsies in children, young people and adults. April 2022 [internet publication]Full text

110. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 Jul 24;160(14):2101-7Full text  Abstract

111. Clarke DM, Currie KC. Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence. Med J Aust. 2009 Apr 6;190(S7):S54-60 Abstract

112. National Institute for Health and Care Excellence. Depression in adults with a chronic physical health problem: recognition and management. October 2009 [internet publication]Full text

113. Prina AM, Cosco TD, Dening T, et al. The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review. J Psychosom Res. 2015 Jan;78(1):25-33Full text  Abstract

114. Archer G, Kuh D, Hotopf M, et al. Association between lifetime affective symptoms and premature mortality. JAMA Psychiatry. 2020 Aug 1;77(8):806-13.Full text  Abstract

115. Machado MO, Veronese N, Sanches M, et al. The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses. BMC Med. 2018 Jul 20;16(1):112Full text  Abstract

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