Falls from a standing height account for a significant majority of hip fractures in older people.[12]Court-Brown C, McQueen M, Tornetta P III. Trauma, 1st ed. Orthopaedic surgery essentials series. Philadelphia, PA: Lippincott Williams & Wilkins; 2006.[13]Allander E, Gullberg B, Johnell O, et al. Falls and hip fracture. A reasonable basis for possibilities for prevention? Some preliminary data from the MEDOS study Mediterranean Osteoporosis Study. Scand J Rheumatol Suppl. 1996;103:49-52.
http://www.ncbi.nlm.nih.gov/pubmed/8966490?tool=bestpractice.com
This is associated with the osteopenic or osteoporotic condition of bone.[20]Court-Brown CM, Caesar B. Epidemiology of adult fractures: a review. Injury. 2006 Aug;37(8):691-7.
http://www.ncbi.nlm.nih.gov/pubmed/16814787?tool=bestpractice.com
[21]Cummings SR, Black DM, Rubin SM. Lifetime risks of hip, Colles', or vertebral fracture and coronary heart disease among white postmenopausal women. Arch Intern Med. 1989 Nov;149(11):2445-8.
http://www.ncbi.nlm.nih.gov/pubmed/2818106?tool=bestpractice.com
[22]Zhao Y, Shen L, Ji HF. Alzheimer's disease and risk of hip fracture: a meta-analysis study. Sci World J. 2012;2012:872173.
http://www.hindawi.com/journals/tswj/2012/872173
http://www.ncbi.nlm.nih.gov/pubmed/22629218?tool=bestpractice.com
See Osteoporosis. Studies suggest an increased risk of hip fracture among patients with dementia.[22]Zhao Y, Shen L, Ji HF. Alzheimer's disease and risk of hip fracture: a meta-analysis study. Sci World J. 2012;2012:872173.
http://www.hindawi.com/journals/tswj/2012/872173
http://www.ncbi.nlm.nih.gov/pubmed/22629218?tool=bestpractice.com
In one population-based study, patients with dementia with coexistent osteoporosis were at increased risk of hip fracture compared with patients with dementia alone.[23]Wang HK, Hung CM, Lin SH, et al. Increased risk of hip fractures in patients with dementia: a nationwide population-based study. BMC Neurol. 2014 Sep 12;14:175.
https://www.doi.org/10.1186/s12883-014-0175-2
http://www.ncbi.nlm.nih.gov/pubmed/25213690?tool=bestpractice.com
In younger people, the primary aetiology is high-energy trauma including motor vehicle accidents and falls from a height.[17]Robinson CM, Court-Brown CM, McQueen MM, et al. Hip fractures in adults younger than 50 years of age: epidemiology and results. Clin Orthop Relat Res. 1995 Mar;(312):238-46.
http://www.ncbi.nlm.nih.gov/pubmed/7634609?tool=bestpractice.com
Fracture pathophysiology includes cortical disruption, periosteal damage, and damage to the intramedullary and cancellous architecture. Histomorphometric studies have shown that cortical thinning and some decrease in trabecular bone mass and connectivity can be seen especially in osteoporosis suggesting a lower quality of bone, and therefore decreased mechanical strength resulting in fracture.[24]Blain H, Chavassieux P, Portero-Muzy N, et al. Cortical and trabecular bone distribution in the femoral neck in osteoporosis and osteoarthritis. Bone. 2008 Nov;43(5):862-8.
http://www.ncbi.nlm.nih.gov/pubmed/18708176?tool=bestpractice.com
An age-related decline in osteocyte viability has also been observed in experimental studies.[25]Dunstan CR, Somers NM, Evans RA. Osteocyte death and hip fracture. Calcif Tissue Int. 1993;53 Suppl 1:S113-6; discussion S116-7.
http://www.ncbi.nlm.nih.gov/pubmed/8275364?tool=bestpractice.com
An inflammatory response also occurs following fractures of the proximal femur.[26]Zgoda M, Gorecki A, Bartlomiejczyk I, et al. Femoral neck fracture is accompanied by local changes in the content of transforming growth factor-beta1, interleukin-1beta and collagenase activity. J Musculoskelet Neuronal Interact. 2007 Apr-Jun;7(2):161-5.
http://www.ncbi.nlm.nih.gov/pubmed/17627086?tool=bestpractice.com
Classify fractures radiographically into intracapsular and extracapsular to guide surgical management.
Intracapsular fractures
The retinacular vessels that pass up the femoral capsule may be damaged, especially if the fracture is displaced, resulting in poor blood supply to the femoral head often leading to avascular necrosis.[1]Parker M, Johansen A. Hip fracture. BMJ. 2006 Jul 1;333(7557):27-30.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488757
http://www.ncbi.nlm.nih.gov/pubmed/16809710?tool=bestpractice.com
Extracapsular fractures
Fractures may be further subdivided, depending on the level of the fracture and the presence or absence of displacement and comminution.[1]Parker M, Johansen A. Hip fracture. BMJ. 2006 Jul 1;333(7557):27-30.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488757
http://www.ncbi.nlm.nih.gov/pubmed/16809710?tool=bestpractice.com
The Garden classification categorises intracapsular hip fractures into four types based on anteroposterior radiographs of the hip. It incorporates displacement, fracture completeness, and relationship of bony trabeculae in the femoral head and neck.[3]Garden RS. Low angle fixation in fractures of the femoral neck. J Bone Joint Surg. 1961 Nov;43(4):647-63.
https://online.boneandjoint.org.uk/doi/pdf/10.1302/0301-620X.43B4.647
[4]Kazley JM, Banerjee S, Abousayed MM, et al. Classifications in brief: garden classification of femoral neck fractures. Clin Orthop Relat Res. 2018 Feb;476(2):441-5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259691
http://www.ncbi.nlm.nih.gov/pubmed/29389800?tool=bestpractice.com
Intracapsular (femoral neck) fractures can be classified as follows:[5]Garden RS. Reduction and fixation of subcapital fractures of the femur. Orthop Clin North Am. 1974 Oct;5(4):683-712.
http://www.ncbi.nlm.nih.gov/pubmed/4606995?tool=bestpractice.com
Type 1: impacted in valgus
Type 2: undisplaced
Type 3: displaced <50% and in varus
Type 4: completely displaced.
Reliability studies have suggested there is poor inter- and intra-rater agreement in categorising fractures with this classification.[6]Beimers L, Kreder HJ, Berry GK, et al. Subcapital hip fractures: the Garden classification should be replaced, not collapsed. Can J Surg. 2002 Dec;45(6):411-4.
https://www.canjsurg.ca/content/45/6/411.long
http://www.ncbi.nlm.nih.gov/pubmed/12500914?tool=bestpractice.com
Extracapsular fractures are classified broadly into trochanteric and subtrochanteric types. The AO classification is useful in further guiding surgical management.[7]Meinberg EG, Agel J, Roberts CS, et al. Fracture and dislocation classification compendium – 2018. J Orthop Trauma. 2018 Jan;32 Suppl 1:S1-170.
http://www.ncbi.nlm.nih.gov/pubmed/29256945?tool=bestpractice.com
This categorises fractures according to location, joint involvement, fracture pattern, and geometry.