Complications
This is usually a rate-related phenomenon associated with the infusion of digoxin-specific antibody (Fab) fragments minutes after infusion is started. A membrane filter will reduce the risk of a reaction. If the reaction occurs, the infusion needs to be stopped and restarted at a slower rate.
Atrial fibrillation (AF) occurs at a median of 7 days after therapy with digoxin-specific antibody (Fab) fragments, affecting about 2% of treated patients in one study.[35] Patients who have been treated with digoxin-specific antibody (Fab) fragments are monitored for development of uncontrolled AF or worsening heart failure and given additional treatment as required.
There have been reported cases of patients who had cardiac arrest with prolonged resuscitation who received digoxin-specific antibody (Fab) fragments after the arrest and recovered.[30]
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