Testosterone for depression . . . and other stories
BMJ 2020; 370 doi: https://doi.org/10.1136/bmj.m3341 (Published 03 September 2020) Cite this as: BMJ 2020;370:m3341
Transdermal testosterone for depression
Small studies suggested that low doses of testosterone improved symptoms in women suffering from depression. But, as so often happens, the hypothesis didn’t survive testing in a larger trial. In women aged 21-70 with treatment-resistant major depression, eight weeks of treatment with transdermal testosterone cream was no better than placebo in reducing depressive symptoms, lessening fatigue, or improving sexual function (Am J Psych doi:10.1176/appi.ajp.2020.19080844).
Fluoxetine after stroke
The idea that fluoxetine might aid recovery after stroke has followed a similar trajectory. In vitro studies suggested that the drug enhanced neuronal plasticity, and a small …
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