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ORIGINAL ARTICLE
Open access

Pathological Characterisation of Posterior Cortical Atrophy in Comparison With Amnestic Alzheimer's Disease

  •  2 April 2025

Graphical Abstract

Pathological Characterisation of Posterior Cortical Atrophy in Comparison With Amnestic Alzheimer's Disease Issue 2, 2025

There was a higher load of Aβ and tau in the parietal region of posterior cortical atrophy (PCA-AD) compared to amnestic AD (a-AD). In the PCA-AD compared to the a-AD group, there were significant increases in tau load in parietal and frontal relative to temporal regions. There was a significantly lower temporal CD68 load in a-AD compared with PCA-AD. This study demonstrates differences in the distribution of Aβ and tau, and variations in regional neuroinflammatory response in PCA-AD and a-AD.

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