Knowledge application and transfer is one of the ultimate learning goals in education. For adult learners, these abilities are not only beneficial but also critical. The ability to apply knowledge learned from school is only a basic requirement in workplaces. In this ever-changing world, the ability to near and far transfer knowledge is the skill that keeps an individual competitive and indispensable in job markets. Therefore, in workplaces, learning transfer is not just a higher order cognitive ability; it is a survival skill. Problem-based learning (PBL) is a pedagogy that could provide an effective learning environment to help students develop these skills. In this chapter, the author will first discuss some basic concepts of learning transfer, followed by a brief discussion of the nature and features of PBL. He will then analyze how the features of PBL could address the issues of failure of learning transfer. Finally, he will provide some instructional design guidelines for using PBL to enhance students' learning transfer.