This study reports on an investigation of barriers that prevent Historically Black Colleges and Universities (HBCUs) from fully participating in the federal disability and rehabilitation research and development (R&D) agenda. The Delphi technique was used to examine panelists' perceptions on the importance of contextual R&D barriers ensuing from policy/systems issues across 13 different categories. The findings provide information about what Federal research entities (e.g., National Institute on Disability and Rehabilitation Research) and HBCU administrators can do to more effectively address the Section 21 Legislative Mandate of the 1992 Rehabilitation Act Amendments and stimulate competitive R&D participation across the HBCU community. (Contains 6 tables.)