Developments in computer and information technologies continue to give opportunities for designing advanced E-learning systems while entailing objective and technical evaluation methodologies. Design and development of E-learning systems require time-consuming and labor-intensive processes; therefore any decision about these systems and their analysis needs systematic and structured guidance to lead to better decisions. Multi-Criteria Decision Analysis (MCDA) techniques are applicable in instructional technology-related research areas as well as in other academic disciplines. In this study, a conceptual domain model and a decision activity framework is proposed for E-learning systems. Instructional, technological, and administrative decision domains are included in this model. Finally, an illustrative example is given to show that AHP is an effective MCDA method for E-learning-related decisions. (Contains 4 figures and 9 tables.)