Although mixed methods designs have gained visibility in recent years, most of the publications on this methodological strategy have been written by scholars in the developed world. Consequently, the practical challenges associated with mixed methods research in developing countries have not been adequately discussed in the literature. Relying on a case study in Ghana, this article examines the benefits and challenges of combining quantitative and qualitative approaches in a single research. The article also demonstrates how the positionality of a mixed methods researcher varies from one context to another. Based on the findings of this study, some recommendations have been made for managing the challenges associated with mixed methods researches.