The growing need for intercultural literacy in an increasingly interconnected and computer-mediated world contrasts with the dearth of investigation in best practices when designing simulations aimed at improving intercultural communication. Synthetic cultures inspired by real-world cultural traits, problem-based learning, and a social constructivist theoretical base represent core components of immersive learning environments designed to improve intercultural literacy. Through an analysis of the literature, a model is proposed primarily to promote discussion and debate about intercultural simulations. The Model for Intercultural Communication in Simulations asserts that along with those components, the Experiential Learning Cycle (ELC), natural decision making, and "third place" thinking form an approach in understanding how intercultural simulations should be designed. The Model for Intercultural Communication in Simulations challenges the learner to move beyond known paradigms and encourages simulation and e-learning designers to employ socially situated contexts. Accordingly, within the context of the model, a culminating evaluation of an online intercultural training simulation ("ARGONAUTONLINE") follows the introduction of the model. (Contains 6 figures and 1 note.)