This study examined the effect of a 10-week physical exercise program on the health status of college staff. Eighty-one participants were pre-tested on 22 variables including physical fitness, biochemical status, psychological health, and morphological measures. Participants in an experimental group (n = 61) received a 10-week intervention consisting of aerobic activities and weight training whereas the remainder (n = 20) constituted a control group. The intervention program was monitored and controlled using the Cooper points system so that the exercise intensity increased gradually and the exercise session duration decreased across the ten weeks. The posttest results indicated that the experimental group had significant improvement on most of the 22 variables, but there was no improvement in any variable within the control group. In addition, those with more than three coronary artery disease risk factors, emotional exhaustion, or high waist-hip ratio in the experimental group improved in most of the variables as well. Finally, the findings demonstrated significant correlations between change in training intensity and change in selected variables for those with both emotional exhaustion and more than three risk factors of coronary artery disease in the experimental group. (Contains 3 tables.)