Chronically high rates of new and experienced science teacher attrition and the findings of new large-scale mentoring programs indicate that administrators should adopt new approaches. A science teacher's role encompasses demanding responsibilities, such as observing laboratory safety and OSHA mandates, as well as management of a business-like, yet engaging, hands-on classroom environment. When added to the challenges experienced by all new teachers, these science-specific challenges can contribute to a science teachers' decision to abandon teaching. This study summarizes data from reports of the US Department of Education, state, other federal, private and professional societies on teacher attrition and new mentoring models. It describes successful features of programs and recommends how they can be delivered economically. When senior-level science teachers are provided pay incentives and some release time, they can become discipline-specific mentors, helping to ensure successful retention of new teachers and providing motivation for experienced teacher to postpone leaving. Pairing experienced science teachers, using electronic media, providing recognition, providing additional time or assistance to gain control of the laboratory, and supporting new teachers in joining appropriate professional groups are strategies described in this paper. (Contains 1 figure.)