Background: Given rising expectations for higher education institutions to rely more on private sources of funding, there is a search for viable models and directions that promise success. But the models used by successful institutions are often unique and not applicable to institutions needing guidance. Aims or focus of discussion: The aim of this paper is to review the development of Webster University, as a case example of how it has met the complex challenges facing private higher learning institutions. The analysis seeks to identify themes and guiding principles that can benefit other institutions. Arguments / comments / suggestions: Five themes explain how Webster University developed from its origin as a small Catholic college in 1915, to achieve its status today as a vibrant, independent, international university with 107 campuses and worldwide enrollment of 21,000. The themes include: (1) commitment to a clear mission; (2) global education programs; (3) diversity of students; (4) personalized learning; and (5) embedded technologies. The themes are conceived as guiding principles that can be shaped and customized to the needs, characteristics, and the particular circumstances of other institutions. The themes also have room for many creative solutions and directions, yet unknown or untested. Conclusion: The case study of Webster University's development gives credence and validation for other institutions to trust the visionary thinking, creative energies, resourcefulness, and commitment of everyone involved toward a viable, relevant and successful institution for the 21st century.