This paper discusses the findings of a research study concerning the use of e-portfolios to develop independent learning, from the perspectives of teachers and students in a Hong Kong university. While most of the findings confirm the value of e-portfolio practice reported in other contexts, they throw into relief a complicated interplay and conflict of factors that may thwart the good intentions of e-portfolio design and implementation. Insights derived from this research will illuminate the issues about e-portfolio-mediated independent learning across a range of settings and learners.