It is globally expected that universities will ensure that policies guiding researchers' conduct are in place and adhered to. This expectation is not waived in developing countries. Successful implementation of an ethics policy is facilitated by an appropriate national regulatory framework on which to base the argument for compliance. However, it is possible to implement such policies even when a regulatory framework is absent. The University of Botswana implemented a program to increase awareness of research ethics and to manage allegations of research misconduct through a needs assessment and seminars on the Responsible Conduct of Research (RCR). This paper describes this problem, and the success of the program initiated to address it. This program serves as a model for other research institutions in the developing world that may encounter similar challenges. (Contains 4 tables and 1 figure.)