Research Findings: Effective teaching in early childhood (EC) care and education settings requires skillful combinations of explicit instruction, sensitive and warm interactions, responsive feedback, and verbal engagement intentionally directed to ensure children's learning and embedded within a classroom environment that is not overly structured or regimented. These aspects of instruction and interaction uniquely predict gains in young children's literacy, language, and social development, effectively contributing to closing gaps in performance between low- and high-risk children. Less clear is an articulation of the ways in which various types of teacher-child interactions within EC settings independently "and" in combination contribute to children's development. Practice or Policy: In this article, we argue that conceptualizing this system of contextual inputs and developmental outputs in a purely aligned way (e.g., social inputs [right arrow] social development; instructional inputs [right arrow] academic development) constrains understanding of both the pathways through which educational experience may influence development as well as the basic processes that may integrate developmental change in what appear to be phenotypically different outcome domains (e.g., social, self-regulatory, academic). (Contains 2 figures.)