The authors asked 55 second-generation Chinese American adolescents (M age = 16.8 years) and 58 European American adolescents (M age = 17.0 years) to complete self-report measures of stress levels, use of coping strategies, psychological outcomes, and grades. Chinese American adolescents reported higher levels of everyday life event stress (e.g., stress from schoolwork), more depression, and higher grade point averages. Problem-focused and avoidance-coping behaviors moderated the effect of stress on negative adjustment for Chinese American youth but not for European American youth. Path analysis showed that avoidance coping behavior partially mediated the stress-to-negative adjustment relationship for Chinese American youth but not for European American youth. Stress was associated with lower grades in Chinese American youth, but the authors found no association for European American youth. (Contains 2 tables and 6 figures.)