Over the last 20 years, the clinical teams at The ChildTrauma Academy have been adapting their clinical practice to be better informed by the core principles of neurodevelopment and neuroscience. The hope is that by better understanding how the brain changes they will better understand the effects of maltreatment on the child and, thereby, potential strategies for effective intervention. As teams have moved from a traditional medical model approach to severely traumatized and maltreated children to more developmentally sensitive, neurobiology-guided practices, the outcomes for clients have significantly improved. The current iteration of this approach is coined The Neurosequential Model of Therapeutics (NMT). This article features the Neurosequential Model of Therapeutics, a developmentally sensitive, neurobiologically informed approach to clinical work that maps the neurobiological development of maltreated children. The goal of this approach is to structure the assessment of the child, articulation of the primary problems, identification of key strengths, and application of interventions (educational, enrichment and therapeutic) in a way that will help family, educators, therapists, and related professionals best meet the needs of the child. (Contains 2 figures.)