Over the past decade, many colleges and universities have invested heavily in information technology in the belief that it would enhance learning and enrich the student experience. Several recent high-profile reports and articles, however, argue that most investments in technology have not paid off. Part of the reason for this pattern of failed investments is the absence of positive role models and clear best practices. Amidst the many stories about promising opportunities or the failures of promise, few concrete models have been offered for how technology can positively enhance teaching and learning. This absence of highly visible successes and best practices increases the sense of frustration and concern and leaves institutions without a lodestar. Some institutions, however, have approached technology carefully and strategically and are successfully transforming teaching and learning. DePauw University in Greencastle, Indiana, offers one story of success. Several years ago, DePauw faculty, students, and staff recognized the potential of technology to enrich learning and grasped that DePauw's historic mission as a liberal arts college required graduating students prepared to succeed and thrive in a broadly digital culture. Consequently, DePauw established the goal of becoming a national model for using technology to enhance liberal arts education and to enrich the college experience. To set the right philosophical and procedural frame, DePauw named its initiatives 361 degree to capture the goal of preparing students for every path of life after graduation (the 360 degrees) and to create new paths (the additional degree of leadership and innovation). From the beginning, the programs focused on alignment with the institution's historic culture, values, and mission--a dedication to effective teaching and learning and to a liberal arts education designed to prepare students for life's work. There would be no technology for technology's sake at DePauw. Over the past four years, the 361 degree programs have done much to extend, enliven, and enhance teaching and learning at DePauw. DePauw's model represents only one of many successful approaches. This article discusses 10 simple factors that offer a well-established list of best practices. (Contains 13 endnotes.)