Objective: The authors measured the prevalence of depressive symptoms among dental students at a historically black college in the United States to determine how depressive symptoms, stress, and social support influence each other within this student population. Participants: Dental students (n = 143) completed a self-administered survey to assess depressive symptoms, stress, and social support, using validated and reliable instruments. Participants also reported demographic variables. Methods: The authors used multivariable linear regression controlling for potential confounding. Results: The prevalence of depressive symptoms was 16.7%. There were significantly higher levels of stress for students with depressive symptoms compared with those without such symptoms (p less than 0.01), and students with depressive symptoms had significantly lower levels of social support (p less than 0.01). Results show higher levels of depressive symptomatology to be related to decreased social support at both high and low stress levels (p less than 0.01). Conclusions: Stress and social support are associated with depressive symptoms among dental students. (Contains 2 tables.)