Effective statistical collaboration in a multidisciplinary health research environment requires skills not taught in the usual statistics courses. Graduates often learn such collaborative skills through trial and error. In this paper, we discuss the development of a biostatistical collaboration course aimed at graduate students in a Health Research Methodology PhD program with Specialization in Biostatistics. The objectives of the course are to promote enthusiasm and commitment to excellence in statistical collaboration in clinical research; to enhance communication of statistical issues to non-statistician collaborators; to build statistical self-sufficiency and develop skill in applied statistics; and to enhance a culture of collaboration among statisticians and non-statistician researchers. The course uses a combination of lectures and tutorials led by faculty members, videotaped consulting practice sessions, and internship with mentoring of each student by an experienced biostatistician. (Contains 1 table and 1 figure.)