The teacher leaders and school administrators at Nipher Middle School in Kirkwood, Missouri, have recently embraced a new set of strategies for supporting learning for all students. During the weekly problem-solving conversations that are a part of their response-to-intervention model, it became evident that clusters of students with unique and previously unrecognized needs were emerging. Recognizing those clusters of students started a conversation about how to meet those students' specific needs and how to fill the gaps so that maximum learning could take place. Microtrend targeting gives school leaders another strategy to use on the long road to filling the gaps and supporting all students. In schools, a microtrend is a small group of students who share similar characteristics and who can benefit from a specific set of interventions. This article discusses four microtrends found in Nipher's student population: (1) childhood obesity; (2) natural disasters and military deployment; (3) mental illness; and (4) information cycle. Looking at these specific concerns in this way has helped Nipher establish clustered interventions that produce powerful results.