Few studies have examined how raising grandchildren influences the marital relationship of grandparent caregivers although half of such caregivers are married. This study used national survey data from Midlife Development in the United States (MIDUS) to contrast perceptions of spousal support and strain for grandparents who had recently provided care for grandchildren along with their own young children (n = 16), and grandparents who had recently cared for grandchildren only (n = 96). Results revealed an interaction between caregivers' sex and family situation with grandmother caregivers who were raising both their own minor children and grandchildren reporting less spousal support than grandfathers in the same situation. Differences on the spousal strain dimension were not significant. Grandmother caregivers occupying 2 caregiving roles appear to have a unique experience with caring for grandchildren. These results parallel other studies that show that grandparent caregivers have poorer outcomes when they hold multiple caregiving roles simultaneously. (2 tables and 1 figure.)