Abduction is a method of reasoning that people use under uncertainty in a context in order to come up with new ideas. The use of abduction in this exploratory study is twofold: (i) abduction is a cross-disciplinary analytic tool that can be used to explain certain key aspects of human-computer interaction in advanced Information Society Technology (IST) environments; (ii) abduction is probably the central inferential mechanism at work when learners learn or in general make sense of things in an IST or mobile context. Consequently, abduction illuminates the special epistemological circumstances of IST enhanced learning, in particular when the learning materials and the learning environment have been arranged in accordance with constructivist pedagogical guidelines. A study of abductive reasoning will help us better understand IST enhanced learning and IST user behaviour as well as give us some valuable hints to the design of human-computer interaction in general. (Contains 6 figures.)