Objective: To address the issue of how much psychiatric residents should be taught about older medications. Methods: Selective use of the literature, including historical overview, was employed to compare and contrast old and newer generation medications. Results: While many old drugs are truly antiquated, medications such as typical antipsychotics, tricyclic and monoamine oxidase antidepressants, and lithium should remain integral parts of a psychopharmacology teaching program. Conclusion: A proper blending of knowledge about older and newer medications and the use of older and newer medications is in the best interest of patients in need of psychopharmcotherapy.