Significant barriers exist to the implementation of evidence-based practices into routine mental health and substance abuse settings. This paper discusses the role and function of technical assistance centers to help support the implementation process using, as a guide, the experience of the Ohio Substance Abuse and Mental Illness Coordinating Center (SAMI CCOE) in helping mental health and substance abuse agencies to implement Integrated Dual Disorders Treatment (IDDT), an evidence-based practice for adults with co-occurring substance and mental disorders A description of the SAMI CCOE is presented followed by discussion of an implementation framework, using stages of organizational change, to help understand and guide the process of implementing evidence-based practices. The paper concludes with a discussion of lessons learned in helping organizations to implement integrated treatment for adults with co-occurring disorders. (Contains 1 figure.)