The purpose of this study is to determine the latent structure of the California Verbal Learning Test-Second Edition (CVLT-II; Delis, Kramer, Kaplan, & Ober, 2000) at three different age levels, using the standardization sample. Maximum likelihood confirmatory factor analyses are performed to test four competing hypothetical models for fit and parsimony. A four-factor model consisting of Attention Span, Learning Efficiency, Delayed Memory, and Inaccurate Memory provides the best fit to the data at two age levels (16-30 years and 31-60 years, respectively) but the factor structure is somewhat less robust in the oldest age group (greater than 60 years). The results clarify the latent structure of the CVLT-II and suggest that a multifactorial interpretation of quantitative and qualitative indexes from this instrument is appropriate for clinical practice with most adults, although findings may need to be interpreted more cautiously among older persons. (Contains 5 tables and 1 note.)