The purpose of this study was to examine preschool caregivers' perceptions of the effect of gender on literacy skills. The five caregivers selected for the study were all female and full-time employees of the preschool. Case studies (including interviews, observations, and documentation) of each of the caregivers were conducted to examine their perceptions of the effect of the gender on literacy. It is apparent that gender can affect the development of literacy proficiency, even in preschool-aged children. Further research should be conducted to determine the factors impacting the areas of reading strategies utilized by students during literacy activities and differences in self-perceptions of literacy proficiency.