Recent changes in federal policy and the proliferation of empirically based interventions (EBIs) designed to prevent problems and promote student academic and behavioral success have created an unprecedented opportunity for schools to expand their use of comprehensive strategies to meet the academic and behavioral health needs of all students. The articles in this timely and important special series suggest that achieving this outcome will be possible only if there is significant systemic reform in educational settings. In this article, the authors argue that necessary systemic reforms include establishing a public health approach to education, expanding consumers' knowledge regarding the availability and selection of EBIs, revising the roles of professionals working in educational settings, creating the infrastructure necessary to implement and sustain EBIs, and using data to drive decision making. (Contains 1 figure.)