Despite on-going calls for developing cultural competency among mental health practitioners, few assessment instruments consider cultural variation in psychological constructs. To meet the challenge of developing measures for minority and international students, it is necessary to account for the influence culture may have on the latent constructs that form a given instrument. What complicates matters further is that individual factors (e.g., gender) within a culture necessitate additional refinement of factor structures on which such instruments are based. The current work endeavors to address these concerns by demonstrating a mixed-methods approach utilized to assess construct validation within a specific culture; and in turn develop culturally-specific instruments. Qualitative methods were used to inform the development of a structured self-report by gaining detailed knowledge of the target culture and creating items grounded in interview and observational data. Factor analysis techniques and triangulation with qualitative analyses validated these findings. Previous work (Sarkar, 2003) suggested a number of gender-specific perceptions of mental health constructs within the target culture and these were investigated using additional mixed-method analyses. This article demonstrates an emerging mixed-method technique for developing culturally sound assessment tools, offers guidance on how to incorporate the overall approach in assessment, and provides a basis for thinking critically about the use of existing instruments when working with diverse populations.