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ERIC Number: EJ767972
Record Type: Journal
Publication Date: 2006
Pages: 6
Abstractor: Author
ISBN: N/A
ISSN: ISSN-1072-0502
EISSN: N/A
Prior Cocaine Exposure Disrupts Extinction of Fear Conditioning
Gugsa, Nishan; Schoenbaum, Geoffrey; Burke, Kathryn A.; Franz, Theresa M.
Learning & Memory, v13 n4 p416-421 Jul-Aug 2006
Psychostimulant exposure has been shown to cause molecular and cellular changes in prefrontal cortex. It has been hypothesized that these drug-induced changes might affect the operation of prefrontal-limbic circuits, disrupting their normal role in controlling behavior and thereby leading to compulsive drug-seeking. To test this hypothesis, we tested cocaine-treated rats in a fear conditioning, inflation, and extinction task, known to depend on medial prefrontal cortex and amygdala. Cocaine-treated rats conditioned and inflated similar to saline controls but displayed slower extinction learning. These results support the hypothesis that control processes in the medial prefrontal cortex are impaired by cocaine exposure.
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A