To differentiate is to make different, distinct, or specialized (Costello, 1994). Differentiation has become popular in education as an instructional philosophy aimed at equitably meeting the learning needs of all students in the classroom. Differentiated planning and delivery of classroom guidance is also necessary for appropriate school counselor practice. This article reviews the literature on classroom guidance, describes the concept of differentiation, and provides applied examples of differentiated classroom guidance for school counselor practice. (Contains 2 tables.)