The influences of domain-specific meteorological knowledge and general visual-spatial abilities on the comprehension of simple weather maps were examined in a regression-based study involving a sample of participants with relatively low meteorological knowledge and in an experiment involving a contrast between samples of higher- and lower-knowledge participants. Results from the first study indicated that the roles of domain-specific knowledge and visual-spatial abilities for lower-knowledge individuals were strongly influenced by the presence of supporting geographic information (i.e., city locations) in the weather maps being interpreted. Results from the second study underscored the importance of domain-specific meteorological knowledge and map familiarity and, surprisingly, pointed to a single visual-spatial ability (speed of closure) that mediated both of these influences.